A heavy police presence was in the St Matthews area during Tuesday (23 October) after a gunshot.
A single shot from a shotgun went through the door of a house in Browning Road off Ribbleton Lane.
No one was injured in the shooting which took place around 2am on Tuesday.
A vehicle believed to have been used was seen driving away at speed.
Preston Police say they believe it is a targeted attack and on Tuesday evening arrested a man and a woman.
Detective Chief Inspector Richard McCutcheon of Lancashire Police said: “We have launched an investigation following this incident and I would appeal to anyone who saw or heard anything suspicious or who has information which could assist to get in touch.
“It is only by good fortune that no-one was seriously hurt or even killed in this incident and we will do all we can to find those responsible. This reckless behaviour will simply not be tolerated.
“I would reassure people that this incident was not directed at the general public and appears to be a targeted attack.”
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Anyone with information should contact police on 101 quoting log 0070 of October 23rd or independent charity Crimestoppers on 0800 555 111.