A fatality on the line near Milton Keynes has caused delays and cancellations to mainline services throughout Sunday evening.
Virgin Trains said major disruption was expected through the evening after the incident on the West Coast mainline.
Dozens of passengers at Preston Railway Station appear stuck after many mainline trains are cancelled on Bonfire Night.
Pictures taken at the station, located on Fishergate, show many passengers stranded on the platforms and in the main entrance as departure boards highlighted cancellations or major delays to trains.
One train, the 17:42 to Glasgow Central, was delayed until 19:10, with others delayed by up to an hour. Another, the 17:53 to Edinburgh is currently delayed by over 2 hours.
Read more: British Transport Police investigated over man’s death at Preston Station
Blog Preston counted at least three departures that were cancelled, and most lines to Manchester appear to be swapped for replacement buses as part of planned rail works.
The after effect of an earlier incident has disrupted trains through #Preston
Check https://t.co/Z4Bb8czro7 before travel if practicable. pic.twitter.com/wBs3Rsb9un
— BTP Lancashire (@BTPLancs) November 5, 2017
The queue for tickets exceeded 30 people at one point whilst staff appeared to struggle with the large numbers of passengers seeking alternative routes.
An announcement made over the loudspeakers said that the delays were due to a fatality on the tracks near Milton Keynes.