Carly Kirby, from Freckleton and Jordan Kelly, from Blackpool have been arrested on suspicion of conspiracy to supply Class A drugs.
Kirby, 25, is described as 5ft 6in tall and of slim build. She has dreadlocks in her hair and is also known to wear wigs and extensions.
Kelly, 22, is described as 5ft 8in tall of small build and speaks with a Liverpool accent.
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The pair, who have links to Blackpool, the Fylde and Merseyside were believed to be together.
Anyone with information can contact police on 101 or 07866 781019 or email 835@lancashire.police.uk.
Alternatively, independent charity Crimestoppers can be contacted anonymously on 0800 555111 or online at crimestoppers-uk.org.
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