Prezzo at the Capitol Centre in Walton-Le-Dale is set to close.
The high-street chain are closing 22 restaurants, which will see over 200 jobs lost.
Their 178 restaurants have been closed to diners during lockdown, although takeaway and delivery has been offered by some.
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Now, many of the eateries will not open after lockdown.
Private equity company Cain International is closing a number of eateries after it bought the firm back from administrators, in a pre-pack deal to secure its future last week.
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The firm said it took the action to protect the majority of Prezzo’s 2,900 employees, though it resulted in 216 redundancies.
The deal came after Prezzo collapsed into administration after failing to reach agreement with landlords on rent payments, less than two months after Cain International had bought the business.
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