Temporary traffic lights will be in place in Lea Road, Lea, from 11pm tonight (Saturday) till 6am on Monday morning.
Traffic under the railway bridge will be reduced to a single lane to enable Network Rail to carry out work on the railway.
The work is part of the ongoing improvement works taking place on the line between Preston and Blackpool.
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The lights will be removed and both lanes open in time for commuter traffic on Monday.
For updates on the railway improvement work, follow The Great Northern Rail Project on Twitter.