Anyone using the train between Preston, Blackpool and Colne faces disruption during this Sunday.
Northern has announced due to a lack of staff being available it is cancelling dozens of services.
Only one train every two hours will run between Blackpool South and Colne, which stops at Preston.
Replacement buses are being put on for those facing cancellations.
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A spokesman for Northern said: “Unfortunately we have so far had to cancel around 80 services across our network and it is likely more will be cancelled as we continue to plan our services.
“Routes which will see cancellations have been chosen carefully to make best use of resources and to minimise the impact on customers. On each route customers will either have other rail options via Northern and other operators or will have the provision of rail replacement transport.
“The areas most affected are in Liverpool, Lancashire and Greater Manchester and we would like to apologise to customers whose plans and journeys will be disrupted.”
Read more: Closures on the Manchester to Preston line to cause delays this summer
The closures are only for Sunday (5 August).
Passengers on Northern services have spent a long, hot, summer on the railways with delays and cancellations a common theme since a new timetable was introduced in May.
Anyone who has a delay of more than 30 minutes can apply for compensation via the delay repay scheme.