Lancashire Fire & Rescue Service are currently in attendance at a scene in the city centre.
Two fire engines are reportedly using hose reel jets at a scene in Manchester Road close to Church Street.
The incident was reported to Blog Preston at around 12.45pm.
A statement from Lancashire Fire & Rescue Service said: “There was just a rubbish fire in a yard.
“Firefighters were at the scene for about 15 minutes.”
More: Preston city centre road closed off after building fire
It is the third time recently that fire crews have been called to Manchester Road.
Crews were called to a derelict building fire on November 30.
They were called to a similar incident on November 25.