Anyone heading from Preston towards Manchester and Chorley saw major delays on the M61 southbound after a crash.
Lancashire Fire Service had to cut people free from the scene just after Junction 8 at the Chorley junction.
A green car had collided with a highway maintenance vehicle which was on the hard shoulder.
North West Motorway Police said two people had been taken to hospital following the crash. An off-duty paramedic had come to the drivers aid at the scene.
Read more: Frustrated drivers calling 999 about Preston city centre congestion
The incident took place shortly before 10.30am on Sunday (26 November).
All lanes were reopened shortly before 11.45am and traffic is easing.
Police had to issue a warning to drivers not to use the hard shoulder before Junction 8 who were trying to escape the tailbacks.