Major delays are expected as the M6 had been shut at Preston.
Lancashire Police had closed the motorway at Junction 32 southbound.
A lorry jack-knifed on the slip road.
All traffic is being diverted off onto the M55 westbound, and then back onto the M6 via the M55 eastbound.
A car is also thought to be involved in the collision.
The incident took place around 7.40am on Friday (29 September).
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Delays are expected through until around 3pm and delays southbound are already back to Junction 33.
There’s a knock-on effect on the M6 northbound with delays between Junction 31A to Junction 32.
Highways England says they have a team on site to sweep fuel which has been spilt onto the motorway.
At 11am the motorway was fully reopened.